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Z%0U =*#q5O6.LE2Qt\`9y] C Syr5M;; q% 1 F[rNDeȮ8į`Fr-O#qau\ ;$[oz~PMWLw dr#s[ 8OŎЌ/b NߠNޢi=Oa xkxL8 8uh'@7$4 X=@'@'@] eP)P4dT@R(@hK!|_w%rMPb܅ /<9]98|W S~QALR"EV3tii]=,7onl~ m  _5:#jHHE=jTuD-Ͽ#B@L*BL/LsC,.:<`@7A|] mP a3)"p}0p8!LeYe]ɫC+J}YdG|ug bkcK6>Ǣ_OJ^bD[ [_3}0n>d, ψfvǧWoG =1GJ{b fA>[0Qj/F 86x/b9W88"@Q!k(>޴邮@6B_D@5e4_D35Z?# Eni|$OSdp&ˎ8D PVI*@#s mśs(vsh״@Kk3hz 4C5hTP( C4b wj}e^fŒr(C "X2 ˪ ' 4›2@R[z F]e[Y#,x!mv{ml(Ї0"6 [g7aO~쑢3%MlsXZ7 !,"Ϡ}xKnwx}5J5aa - W&#ѥ+N%E;i4rMHmOOU&\𘘑!*,(8/Cty 'cJxm\!c{1O H;l98 /yc_Cp !v C%r9軍2u$abSC}|brL֎'3(? `F4YѕC=(!i?Z^R}Kdb?` f'pbčÊ9y M+cˏ̳8?s(_VU"hLH5׿P{g*a*NX 粒H@,~v%ҦHB w$i\kL#u hϝQU.D淚ӧ@UI=-E&%Ȯ'P!DfBi.q is! ?QCJU?C#+ݟ¬4妑:M24P=0KOf ^C#ȁ QZtF&DQy1gB JdBk2!vZ6`}0< 3dݼe9e 6ߦ6/(Gc[TX TV9δ~"x̞a)|B3^iWw OMkmȹx;vطRs24d07;RYZ1ۥ:YwXw.p7al^6u Ow1spQ( ͫUd= "TK0.e+*GkQC%6}@,,+ s;?.44BppwpHzvU[=IԾ`7s^X""e;F@f˖P];_;{^@Lugq)D/g}2,ǜKJ ptc˞eGwѻ8с4с6ѻnVi3h CӒHG5T,( 5?#mn@i |8OeSDg:ˎ D XEk&)ѻ($sw)@Lw~ViHk@@@k@X1 `tKsMzy4PϡQ5B5B)(j|FHFHFHD%/:=|h#j|WF峂S6 AVWH M=-KIg C\0 ePg/6=|KXM_" O뭋D 5B~]MfВ.]%*7Cu]xVfp×TtHˢ0*qנF HAxڕH ,w:&$7^J+-ʶܲzѲo)oFT :׶(5OnNU80%?tw[9[i.R amG^ET{%)TǨ*uŞ};0% [b`? g ޑl>X: ˏo]~|FViݘ Ga5GKI*ZpR3Uy.A.e/ i&n 6ˬLozE5pT+N@+\;=HIp E(KJRHSr;ֈ~VtiӢ#HAH]|Fs #O#1 fIѵ(2!aAvutq>A"Yg&鳊8-:i͋gEG6@ڴEG::VRG(6Zҁ:ZwwQ˞QEJl)*#/^ JFKURo>e<\'swcpHrvR_e7nJg4#ݲ([);@Y'_9y$3hT79ʉ ar3 sSf(-l#G'z:}^v)AA4AaBY"EGuxKc/I~<6/mAUXKU)կzzU&ԫDz{FW}CfYLb"OX*/fff'n~2>~S(E{rOCG,VhfKhuh3Fi v#O# eIȏLH1ˎI`2//Z3IUhOUlOR}SN#<ٛy"hoZ6{ti&R%yhǍ. ddeJBG\ZfLE{2p"sнPdЄ vWH~1ěfհeeg7vFNfXO{_?ؔd7gm-$ڦ/$/-ZΌPrslT~us?u/7˺v=98krx  d~Ǔx䘾cdUvEOVcQ*8en^Xի\E8^:2<jXtjC&vvΦ3l)v-6Qe#ĺVa{?ï'a{zZyWC_y8GN`g{?9/^lO_B H(ҍ40t849qQw&qExg? fI *dfxQ8x/D-'`-?j]6mF!@vg0)hЈ 0}]<:Foigo d `P^DRx3݅`a6 EdAG^Ֆ~Go_BkH]YݟaO'/~kPfn endstream endobj 103 0 obj << /G3 649 0 R /gs2 561 0 R >> endobj 104 0 obj << /F4 650 0 R /F5 651 0 R /F6 652 0 R >> endobj 105 0 obj << /Length 8878 /Filter /FlateDecode >> stream x]$m5F<imQvm$M_|iQ?fV̈3]r;nHJ#/A?oc*?|wqQMw6t/?O>OۣNU>߼7ӻç_BZ |rAXzTV`:.t{t7ogSD?hs;\ۣ]HDכQхE ;]Gj 8o|=*lo^bDcO#N;Z~iLyw@~-17o31w%Ԁ:si\nЫQĩ`]C?ƏRB s5aׅYg?&tJcWUtd񟎭i9d;. 3'm8 }'?!v}8|qI=m/~vD0q]8ɠy>陶|Vf|yj:U4aLauc*I!(ezR:QVm~ZV]Ђ{o׹;q=GiKROD$~_1E%zkZއ}a[U e i[U7r06[o[tw,( Ce\_ja2-Y;vg 4LF2a4=3}ˤ.3'~:ꭻw^e~b8dbC7{[9Mvmcwx`QĎٳNUYb8غIJ3t].~?Ai!ߌĐEBcx"3dK6n}YlvtWu-02x鮧p`-=>چՃ۹ԳldrPŮ>PgѾʷIG=;6n+ \(n! 0 8z҉=CDlf@((hy/U`҉ $hmCD˽&tB]OhC<?B@h> QT­}Df@E ؋C\!db(50tTy̡'(t 'yC6aA~&t![2D GNܸ&G_QTG,[`tRG[iD+n3S4Öq8YwUkg!OLl]pe|/p5A1ߏ i5HcR_V9ìMm >N,L*YGf-`3̜fTW5s3_mh]bY=W fFA%Hh/r5@8YFbhn) ;5M"xMGS1'yΞf?KDp5'>ĦDD_YhzzI:bgy NE @ޘi~~H,FI˰{$dI^$!Ia7ɫCɐ <>4=/a>0`M\1D̜!M$xy ?2%"4o,ew"V C;Ms\̙qTT !Q#r!udDOy\#3r̶" 2-Qj~ )1%u-,D[X4MCyi~m;z[qvb-L $̚c{3Vu' F +LȎ+UOv' Lkqj>Ld0d$*{ѷlN7ayMVtr -}@͎f"4N09Ps<@:L㙊zP~G4v遌$:T o8 oq^*d2 fE/4Լhy s$bp v-*K?njQTsFPrk:l,G{Нٕ\{(#Utj Gɦ= QzE.";_=χm󋏾?>;ﾛa6{8Zg^ZZ\h45DZ_l'LW- )jmq:Yo4g6j=;zK*K*-lWỲWJ*6HϺr$je7I[WuuX%׳a}{6H9XW)FPR,jĤ\ S+W m$6\ԶiPsI(s1J3qu\$(.iP"/ htS$(3*npꉃ?悝"A1LK K6S<|F`,QE X/w!L&N~L   }  q  C8B\B!W.\3'yPu5A3uh yѯDcn>("s0̪"2(,] ű(3Ly^Ð3H۩ hb2m_Z`rYPdgBɷWU7vT<Zʮ>kxaYF=ݡ YrVb(Ef;B )f)d4Ȇs9VE4VYƓ Vw= 31:@&$ɍU.p28KjZ&[m#1N*TXӧC0]kdN(sC՚ ַ aN鼐%;nT,q#fЍRfOgr_V LRL]JT;EV+B Sc_2Yu$rb1yzAb9mBGAj+W!>ZݧլA:7-ܢ2h@[䢹N-rрsE< h8ŒD :i# @gxaOam#.GG>bɈ8e,R3Ytn\󷋓ݴsCaKHҀKt. M.g*BQ ~@b_ee::څ8 TAIu{'QQ3_@n,0ĜLk6aO߲J.uy3Vmد< ].̶jRI3:Èߺ:nb:LtXW-|6a-XZb6䰁Zxv2C Hՙh?mYRafipnHҴ7Ûk2ñgPwm$HP8LYvb88^9.78gw "z׷V ;y/~ nR߸ 4vo냗;x{[eс)Y^B]-P$w9+mЫ+乀^t宠y]Z(S4H|B-мNS6GD xy@y@[V˴k&h~@}BR/rё"ٻbm2.$a!1zo@,׺8;rEVkX)5QC[n+z!+'4/AKoemQ"Id;.ww4ԶIqϪlVb%d$cX[yr(RFlcWn0f  Pvȍ%#j&s jd3|Kԇ Wj$oў& G*>up{?[k;d(vTo׏Q^qQ:d˂[$}-S84D})GEo!AUi>e P3@ U,DjYC~d*jZO UB+'nBJfTyEP~,|&^>a )e+XV[TIds`,ĶgdD,D"rT"K5yALH iQIs؛/DDIGr|!4ZREz>PY, e0ˀ&|.p$&]qń"TeG6m%huCBvVYtTSG'͉3O#,- kmQd >Id2: z375LNR$ZJp%6W,&Yuٲ"H<ir7dhI]#C`mb\n7}۠loT"̓(-9Qj50Z,h7J?Ծh2GA&#ԡז?H Ճ^ )iCBRe{Cw}vw d;~ޒw߳O6&q%=@7.ԡԭtJCȄ :RtxH`/:3> endobj 107 0 obj << /Type /StructElem /S /Part /P 30 0 R /Pg 8 0 R /K [156 0 R 157 0 R 158 0 R 159 0 R 160 0 R 161 0 R 162 0 R 163 0 R 164 0 R 165 0 R 166 0 R 167 0 R 168 0 R 169 0 R 170 0 R 171 0 R 172 0 R 173 0 R 174 0 R 175 0 R 176 0 R 177 0 R 178 0 R 179 0 R 180 0 R 181 0 R 182 0 R 183 0 R 184 0 R 185 0 R 186 0 R] >> endobj 108 0 obj << /Type /StructElem /S /Part /P 30 0 R /Pg 9 0 R /K [187 0 R 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Front Oncol. 2020 Apr 28;10:659. ) /Pg 25 0 R /K [4] >> endobj 492 0 obj << /Type /StructElem /S /P /P 766 0 R /E (Pathophysiological Role of Transient Receptor Potential Mucolipin Channel 1 in Calcium-mediated Stress-Induced Neurodegenerative Diseases. Santoni G, Maggi F, Amantini C, Marinelli, Nabissi M, Morelli MB. Front Physiol. 2020 Mar 24;11:251. ) /Pg 25 0 R /K [5] >> endobj 493 0 obj << /Type /StructElem /S /P /P 767 0 R /E (Transient Receptor Potential Cation Channels in Cancer Therapy. Santoni G, Maggi F, Morelli MB, Santoni M, Marinelli O. Med Sci \(Basel\). 2019 Nov 30;7\(12\). ) /Pg 25 0 R /K [6] >> endobj 494 0 obj << /Type /StructElem /S /P /P 768 0 R /E (The controversial role of PD-1 and its ligands in endometrial cancer and other gynaecological malignancies. Marinelli O, Annibali D, Aguzzi C, Tuyaerts S, Amant F, Morelli MB, Santoni G, Amantini C, Maggi F, Nabissi M. Front Oncol. 2019 Oct 15;9:1073. ) /Pg 25 0 R /K [7] >> endobj 495 0 obj << /Type /StructElem /S /P /P 769 0 R /E (The TRPV2 Cation Ion Channels: from Urothelial Cancer Invasiveness to Glioblastoma Multiforme Interactome-Signature. Santoni G, Amantini C, Maggi F, Marinelli O, Santoni M, Nabissi M, Morelli MB. Lab Invest. 2020 Feb;100\(2\):186-198. ) /Pg 25 0 R /K [8] >> endobj 496 0 obj << /Type /StructElem /S /P /P 770 0 R /E (Targeting Transient Receptor Potential Channels by MicroRNAs Drives Tumor Development and Progression. Santoni G, Morelli MB, Santoni M, Nabissi M, Marinelli O, Amantini C. Adv Exp Med Biol. 2020;1131:605-623. ) /Pg 25 0 R /K [9] >> endobj 497 0 obj << /Type /StructElem /S /P /P 771 0 R /E (Calcium Signaling and the Regulation of Chemosensitivity in Cancer Cells: Role of the Transient Receptor Potential Channels. Santoni G, Morelli MB, Marinelli O, Nabissi M, Santoni M, Amantini C. Calcium Adv Exp Med Biol. 2020;1131:505-517.) /Pg 25 0 R /K [10] >> endobj 498 0 obj << /Type /StructElem /S /P /P 772 0 R /E (Expression profiling of circulating tumor cells in pancreatic ductal adenocarcinoma patients: biomarkers predicting overall survival. Amantini C, Morelli MB, Nabissi M, Piva F, Marinelli O, Maggi F, Bianchi F, Bittoni A, Berardi R, Giampieri R, Santoni G. Front Oncol. 2019 Sep 10;9:874. ) /Pg 25 0 R /K [11] >> endobj 499 0 obj << /Type /StructElem /S /P /P 773 0 R /E <5472616E7369656E74205265636570746F7220506F74656E7469616C204D75636F6C6970696E2D31204368616E6E656C7320696E20476C696F626C6173746F6D613A20526F6C6520696E2050617469656E74907320537572766976616C2E204D6F72656C6C69204D422C20416D616E74696E6920432C20546F6D6173736F6E6920442C204E616269737369204D2C20417263656C6C6120412C2053616E746F6E6920472E2043616E636572732028426173656C292E2032303139204170722031323B31312834293A3532352E> /Pg 25 0 R /K [12] >> endobj 500 0 obj << /Type /StructElem /S /P /P 774 0 R /E /Pg 25 0 R /K [13] >> endobj 501 0 obj << /Type /StructElem /S /Figure /P 124 0 R /Pg 25 0 R /K [15] >> endobj 502 0 obj << /Type /StructElem /S /H1 /T (PUBLICATION ) /E (PUBLICATION ) /Pg 26 0 R /K [13] >> endobj 503 0 obj << /Type /StructElem /S /P /P 775 0 R /E /Pg 26 0 R /K [0] >> endobj 504 0 obj << /Type /StructElem /S /P /P 776 0 R /E <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> /Pg 26 0 R /K [1] >> endobj 505 0 obj << /Type /StructElem /S /P /P 777 0 R /E (Chemical manipulations on the 1,4-dioxane ring of 5-HT\(1A\) receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells. Del Bello F, Bonifazi A, Giorgioni G, Quaglia W, Amantini C, Morelli MB, Santoni G, Battiti FO, Vistoli G, Cilia A, Piergentili A. Eur J Med Chem. 2019 Apr 15;168:461-473. ) /Pg 26 0 R /K [2] >> endobj 506 0 obj << /Type /StructElem /S /P /P 778 0 R /E (Isofuranodiene synergizes with Temozolomide in inducing glioma cells death. Brunetti A, Marinelli O, Morelli MB, Iannarelli R, Amantini C, Russotti D, Santoni G, Maggi F, Nabissi M. Phytomedicine, 2019 Jan;52:51-59. ) /Pg 26 0 R /K [3] >> endobj 507 0 obj << /Type /StructElem /S /P /P 779 0 R /E (Urinary Markers in Bladder Cancer: An Update. Santoni G, Morelli MB, Amantini C, Battelli N. Front Oncol. 2018 Sep 7;8:362. ) /Pg 26 0 R /K [4] >> endobj 508 0 obj << /Type /StructElem /S /P /P 780 0 R /E (Novel antitumor copper\(II\) complexes rationally designed to act through synergistic mechanisms of action, due to the presence of an NMDA receptor ligand and copper in the same chemical entity. Morelli MB*, Amantini C, Santoni G, Pellei M, Santini C, Cimarelli C, Marcantoni E, Petrini M, Del Bello F, Giorgioni G, Piergentili A, Quaglia W. New J. Chem., 2018, 42, 11878 *CoF ) /Pg 26 0 R /K [5] >> endobj 509 0 obj << /Type /StructElem /S /P /P 781 0 R /E (Thyme extract increases mucociliary-beating frequency in primary cell lines from chronic obstructive pulmonary disease patients. Nabissi M. Marinelli O, Morelli MB, Nicotra G, Innarelli R, Amantini C, Santoni G, Maggi F. Biomed Pharmacother. 2018 Sep;105:1248-1253. ) /Pg 26 0 R /K [6] >> endobj 510 0 obj << /Type /StructElem /S /P /P 782 0 R /E ("Immuno-Transient Receptor Potential Ion Channels": The Role in Monocyte- and Macrophage-Mediated Inflammatory Responses. Santoni G, Morelli MB, Amantini C, Santoni M, Nabissi M, Marinelli O, Santoni A. Front Immunol. 2018 Jun 6;9:1273. ) /Pg 26 0 R /K [7] >> endobj 511 0 obj << /Type /StructElem /S /P /P 783 0 R /E (Aniseed \(Pimpinella anisum L.\) essential oil reduces pro-inflammatory cytokines and stimulates mucus secretion in primary airway bronchial and tracheal epithelial cell lines. Iannarelli R, Marinelli O, Morelli MB, Santoni G, Amantini C, Nabissi M, Maggi F. Industrial Crops and Products. 2018 April;114:81-86.) /Pg 26 0 R /K [8] >> endobj 512 0 obj << /Type /StructElem /S /P /P 784 0 R /E (High CTLA-4 expression correlates with poor prognosis in thymoma patients. Santoni G, Amantini A, Morelli MB, Tomassoni D, Cardinali C, Santoni M, Marinelli O, Nabissi M, Paolucci V, Torniai M, Rinaldi S, Morgese F, Bernardini G, Berardi R. Oncotarget. 2018 Mar 30;9\(24\):16665-16677. ) /Pg 26 0 R /K [9] >> endobj 513 0 obj << /Type /StructElem /S /P /P 785 0 R /E (ICOS-L as a Potential Therapeutic Target for Cancer Immunotherapy. Marinelli O, Nabissi M, Morelli MB, Torquati L, Amantini C, Santoni G. Curr Protein Pept Sci. 2018;19\(11\):1107-1113. ) /Pg 26 0 R /K [10] >> endobj 514 0 obj << /Type /StructElem /S /P /P 786 0 R /E (Evidence of post-trascriptional readthrough regulation in FGF5 gene of alpaca. Pallotti S, Pediconi D, Subramanian D, Molina MG, Antonini M, Morelli MB, Renieri C, La Terza A. Gene. 2018 Mar 20;647:121-128. ) /Pg 26 0 R /K [11] >> endobj 515 0 obj << /Type /StructElem /S /P /P 787 0 R /E (The TRPV1 ion channel regulates thymocyte differentiation by modulating autophagy and proteasome activity.Amantini C, Farfariello V, Cardinali C, Morelli MB, Marinelli O, Nabissi M, Santoni M, Bonfili L, Cecarini V, Eleuteri AM, Santoni G. Oncotarget. 2017 Oct 11;8\(53\):90766-90780. ) /Pg 26 0 R /K [12] >> endobj 516 0 obj << /Type /StructElem /S /Figure /P 125 0 R /Pg 26 0 R /K [14] >> endobj 517 0 obj << /Type /StructElem /S /H1 /T (PUBLICATION ) /E (PUBLICATION ) /Pg 27 0 R /K [11] >> endobj 518 0 obj << /Type /StructElem /S /P /P 788 0 R /E (Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21\(Waf/Cip1\) dependent manner. Morelli MB, Amantini C, Nabissi M, Cardinali C, Santoni M, Bernardini G, Santoni A, Santoni G. Oncotarget. 2017 Jan 10;8\(2\):3380-3395. ) /Pg 27 0 R /K [0] >> endobj 519 0 obj << /Type /StructElem /S /P /P 789 0 R /E (Post-transcriptional regulation of 5'-untranslated regions of human Transient Receptor Potential Vanilloid type-1 \(TRPV-1\) channels: role in the survival of glioma patients. Nabissi M, Morelli MB, Arcella A, Cardinali C, Santoni M, Bernardini G, Santoni A, Santoni G, Amantini C. Oncotarget. 2016 Dec 6;7\(49\):81541-81554. ) /Pg 27 0 R /K [1] >> endobj 520 0 obj << /Type /StructElem /S /P /P 790 0 R /E (Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Nabissi M, Morelli MB*, Offidani M, Amantini C, Gentili S, Soriani A, Cardinali C, Leoni P, Santoni G. Oncotarget. 2016 Nov 22;7\(47\):77543-77557. *CoF ) /Pg 27 0 R /K [2] >> endobj 521 0 obj << /Type /StructElem /S /P /P 791 0 R /E (Evaluation of thyme extract effects in human normal brochial and tracheal epithelial cell lines and in human lung cancer cell line. Marinelli O, Iannarelli R, Morelli MB, Valisi M, Nicotra G, Amantini C, Cardinali C, Santoni G, Maggi F, Nabissi M. Chem Biol Interact. 2016 Aug 25;256:125-33. ) /Pg 27 0 R /K [3] >> endobj 522 0 obj << /Type /StructElem /S /P /P 792 0 R /E (Capsaicin triggers autophagic cell survival which drives epithelial mesenchymal transition and chemoresistance in bladder cancer cells in an Hedgehog-dependent manner. Amantini C, Morelli MB, Nabissi M, Cardinali C, Santoni M, Gismondi A, Santoni G. Oncotarget. 2016 Aug 2;7\(31\):50180-50194. ) /Pg 27 0 R /K [4] >> endobj 523 0 obj << /Type /StructElem /S /P /P 793 0 R /E (Overexpression of Transient Receptor Potential Mucolipin-2 Ion Channels in Gliomas: role in Tumor Growth and Progression. Morelli MB, Nabissi M, Amantini C, Tomassoni D, Rossi F, Cardinali C, Santoni M, Arcella A, Oliva MA, Santoni A, Polidori C, Mariani MP, Santoni G. Oncotarget. 2016 Jul 12;7\(28\):43654-43668. ) /Pg 27 0 R /K [5] >> endobj 524 0 obj << /Type /StructElem /S /P /P 794 0 R /E (Guidelines for the use and interpretation of assays for monitoring autophagy \(3rd edition\).Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Morelli MB et al. Autophagy. 2016 Jan 2;12\(1\):1-222. ) /Pg 27 0 R /K [6] >> endobj 525 0 obj << /Type /StructElem /S /P /P 795 0 R /E /Pg 27 0 R /K [7] >> endobj 526 0 obj << /Type /StructElem /S /P /P 796 0 R /E (Axitinib induces DNA damage response leading to senescence, mitotic catastrophe, and increased NK cell recognition in human renal carcinoma cells. Morelli MB, Amantini C, Santoni M, Soriani A, Nabissi M, Cardinali C, Santoni A and Santoni G. Oncotarget. 2015 Nov 3;6\(34\):36245-59. ) /Pg 27 0 R /K [8] >> endobj 527 0 obj << /Type /StructElem /S /P /P 797 0 R /E (Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells. Amantini C, Morelli MB, Santoni M, Soriani A, Cardinali C, Farfariello V, Eleuteri AM, Bonfili L, Mozzicafreddo M, Nabissi M, Cascinu S, Santoni G. Oncoscience. 2015 Mar 23;2\(4\):395-409.) /Pg 27 0 R /K [9] >> endobj 528 0 obj << /Type /StructElem /S /P /P 798 0 R /E (Cannabidiol stimulates Aml-1a-dependent glial differentiation and inhibits glioma stem-like cells proliferation by inducing autophagy in a TRPV2-dependent manner. Nabissi M, Morelli MB*, Amantini C, Liberati S, Santoni M, Ricci-Vitiani L, Pallini R, Santoni G. Int J Cancer. 2015 Oct 15;137\(8\):1855-69. *CoF ) /Pg 27 0 R /K [10] >> endobj 529 0 obj << /Type /StructElem /S /Figure /P 126 0 R /Pg 27 0 R /K [12] >> endobj 530 0 obj << /Type /StructElem /S /H1 /T (PUBLICATION ) /E (PUBLICATION ) /Pg 28 0 R /K [13] >> endobj 531 0 obj << /Type /StructElem /S /P /P 799 0 R /E (Danger- and Pathogen-associated molecular patterns recognition by ion channels of Transient Receptor Potential family, triggers inflammasome activation in neurons and immune cells. Santoni G, Cardinali C, Morelli MB, Santoni M, Nabissi M, Amantini C. Journal of Neuroinflammation. 2015 Feb 3;12\(1\):21. ) /Pg 28 0 R /K [0] >> endobj 532 0 obj << /Type /StructElem /S /P /P 800 0 R /E (Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation. Morelli MB, Amantini C, Nabissi M, Liberati S, Cardinali C, Farfariello V, Quaglia W, Piergentili A, Bonifazi A, Del Bello F, Santoni M, Mammana G, Servi L, Filosa A, Gismondi A, Santoni G. BMC Cancer. 2014 Dec 7;14:921. ) /Pg 28 0 R /K [1] >> endobj 533 0 obj << /Type /StructElem /S /P /P 801 0 R /E (Epigenetic, Genetic, and Acquired Regulation of Cav3 T-Type Calcium Channel Expression and Function in Tumor Growth and Progression. Morelli MB, Liberati S, Amantini C, Santoni M, Nabissi M, Farfariello V, Santoni G. Book: PATHOLOGIES of CALCIUM CHANNELS 2014: 277-295. ) /Pg 28 0 R /K [2] >> endobj 534 0 obj << /Type /StructElem /S /P /P 802 0 R /E (Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression. Liberati S, Morelli MB, Amantini C, Farfariello V, Santoni M, Conti A, Nabissi M, Cascinu S, Santoni G. Cells. 2014 Feb 19;3\(1\):112-28.) /Pg 28 0 R /K [3] >> endobj 535 0 obj << /Type /StructElem /S /P /P 803 0 R /E (Advances In Transient Receptor Potential Vanilloid-2 Channel Expression And Function In Tumor Growth And Progression. Liberati S, Morelli MB, Amantini C, Santoni M, Nabissi M, Cardinali C, Santoni G. Curr Protein Pept Sci. 2014;15\(7\):732-7.) /Pg 28 0 R /K [4] >> endobj 536 0 obj << /Type /StructElem /S /P /P 804 0 R /E (Resiniferatoxin induces mitochondrial-dependent death of bladder cancer cells and reduces tumor growth in a xenograft mouse model. Farfariello V, Liberati S, Morelli MB*, Tomassoni D, Santoni M, Nabissi M, Giannantoni A, Santoni G, Amantini C.Chem Biol Interact. 2014 Oct 29;224C:128-135. *CA ) /Pg 28 0 R /K [5] >> endobj 537 0 obj << /Type /StructElem /S /P /P 805 0 R /E (The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2. Morelli MB*, Offidani M, Alesiani F, Discepoli G, Liberati S, Olivieri A, Santoni M, Santoni G, Leoni P, Nabissi M. Int J Cancer. 2014 Jun 1;134\(11\):2534-46. *FA ) /Pg 28 0 R /K [6] >> endobj 538 0 obj << /Type /StructElem /S /P /P 806 0 R /E (Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells. Santoni M, Amantini C, Morelli MB, Liberati S, Farfariello V, Nabissi M, Bonfili L, Eleuteri AM, Mozzicafreddo M, Burattini L, Berardi R, Cascinu S, Santoni G. Br J Cancer. 2013 Aug 20;109\(4\):1040-50. ) /Pg 28 0 R /K [7] >> endobj 539 0 obj << /Type /StructElem /S /P /P 807 0 R /E (Expression and Function of the Transient Receptor Potential Ion Channel Family in the Hematologic Malignancies. Morelli MB, Liberati S, Amantini C, Nabissi M, Santoni M, Farfariello V, Santoni G. Curr Mol Pharmacol. 2013 Nov;6\(3\):137-48. ) /Pg 28 0 R /K [8] >> endobj 540 0 obj << /Type /StructElem /S /P /P 808 0 R /E (Essential Role of Gli Proteins in Glioblastoma Multiforme. Santoni M, Burattini L, Nabissi M, Morelli MB, Berardi R, Santoni G, Cascinu S. Curr Protein Pept Sc 2013 Mar; 14: 133-40. ) /Pg 28 0 R /K [9] >> endobj 541 0 obj << /Type /StructElem /S /P /P 809 0 R /E (TRP Channels: New Potential Therapeutic Approaches in CNS Neuropathies. Morelli MB, Amantini C, Liberati S, Santoni M, Nabissi M. CNS Neurol Disord Drug Targets 2013 Mar; 12: 274-93. ) /Pg 28 0 R /K [10] >> endobj 542 0 obj << /Type /StructElem /S /P /P 810 0 R /E (Oncogenic and anti-oncogenic effects of transient receptor potential channels. Liberati S, Morelli MB*, Nabissi M, Santoni M, Santoni G. Curr Top Med Chem. 2013;13\(3\):344-66. *CoF ) /Pg 28 0 R /K [11] >> endobj 543 0 obj << /Type /StructElem /S /P /P 811 0 R /E (The role of transient receptor potential vanilloid type-2 ion channels in innate and adaptive immune responses. Santoni G, Farfariello V, Liberati S, Morelli MB, Nabissi M, Santoni M, Amantini C. Front Immunol. 2013 Feb 14;4:34. ) /Pg 28 0 R /K [12] >> endobj 544 0 obj << /Type /StructElem /S /Figure /P 127 0 R /Pg 28 0 R /K [14] >> endobj 545 0 obj << /Type /StructElem /S /H1 /T (PUBLICATION ) /E (PUBLICATION ) /Pg 29 0 R /K [13] >> endobj 546 0 obj << /Type /StructElem /S /P /P 812 0 R /E (Follicular fluid hormonal profile and cumulus cell gene expression in controlled ovarian hyperstimulation with recombinant FSH: effects of recombinant LH administration. Barberi M, Ermini B, Morelli MB, Ermini M, Cecconi S, Canipari R. J Assist Reprod Genet. 2012 Dec;29\(12\):1381-91. ) /Pg 29 0 R /K [0] >> endobj 547 0 obj << /Type /StructElem /S /P /P 813 0 R /E (New Insight on the Role of Transient Receptor Potential \(TRP\) Channels in Driven Gliomagenesis Pathways. Santoni G, Morelli MB, Amantini C, Santoni M, Nabissi M. Book: Glioma - Exploring Its Biology and Practical Relevance. 2011) /Pg 29 0 R /K [1] >> endobj 548 0 obj << /Type /StructElem /S /P /P 814 0 R /E (Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents. Nabissi M, Morelli MB*, Santoni M, Santoni G. Carcinogenesis. 2013 Jan;34\(1\):48-57. *CoF ) /Pg 29 0 R /K [2] >> endobj 549 0 obj << /Type /StructElem /S /P /P 815 0 R /E (The transient receptor potential vanilloid-2 cation channel impairs glioblastoma stem-like cell proliferation and promotes differentiation. Morelli MB, Nabissi M, Amantini C, Farfariello V, Ricci-Vitiani L, di Martino S, Pallini R, Larocca LM, Caprodossi S, Santoni M, De Maria R, Santoni G. Int J Cancer. 2012 Oct 1;131\(7\):E1067-77. ) /Pg 29 0 R /K [3] >> endobj 550 0 obj << /Type /StructElem /S /P /P 816 0 R /E /Pg 29 0 R /K [4] >> endobj 551 0 obj << /Type /StructElem /S /P /P 817 0 R /E (IL-22 mRNA in peripheral blood mononuclear cells from allergic rhinitic and asthmatic pediatric patients. Farfariello V, Amantini C, Nabissi M, Morelli MB, Aperio C, Caprodossi S, Carlucci A, Bianchi AM, Santoni G. Pediatr Allergy Immunol. 2011 Jun;22\(4\):419-23. ) /Pg 29 0 R /K [5] >> endobj 552 0 obj << /Type /StructElem /S /P /P 818 0 R /E (Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Caprodossi S, Amantini C, Nabissi M, Morelli MB, Farfariello V, Santoni M, Gismondi A, Santoni G. Carcinogenesis. 2011 May;32\(5\):686-94. ) /Pg 29 0 R /K [6] >> endobj 553 0 obj << /Type /StructElem /S /P /P 819 0 R /E (Expression of transient receptor potential vanilloid-1 \(TRPV1\) in urothelial cancers of human bladder: relation to clinicopathological and molecular parameters. Kalogris C, Caprodossi S, Amantini C, Lambertucci F, Nabissi M, Morelli MB, Farfariello V, Filosa A, Emiliozzi MC, Mammana G, Santoni G. Histopathology. 2010 Nov;57\(5\):744-52. ) /Pg 29 0 R /K [7] >> endobj 554 0 obj << /Type /StructElem /S /P /P 820 0 R /E (TRPV2 channel negatively controls glioma cell proliferation and resistance to Fas-induced apoptosis in ERK-dependent manner. Nabissi M, Morelli MB, Amantini C, Farfariello V, Ricci-Vitiani L, Caprodossi S, Arcella A, Santoni M, Giangaspero F, De Maria R, Santoni G. Carcinogenesis. 2010 May;31\(5\):794-803. ) /Pg 29 0 R /K [8] >> endobj 555 0 obj << /Type /StructElem /S /P /P 821 0 R /E (Triggering of transient receptor potential vanilloid type 1 \(TRPV1\) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Amantini C, Ballarini P, Caprodossi S, Nabissi M, Morelli MB, Lucciarini R, Cardarelli MA, Mammana G, Santoni G. Carcinogenesis. 2009 Aug;30\(8\):1320-9. ) /Pg 29 0 R /K [9] >> endobj 556 0 obj << /Type /StructElem /S /P /P 822 0 R /E (Characterization, expression, and functional activity of pituitary adenylate cyclase-activating polypeptide and its receptors in human granulosa-luteal cells. Morelli MB, Barberi M, Gambardella A, Borini A, Cecconi S, Coticchio G, Canipari R. J Clin Endocrinol Metab. 2008 Dec;93\(12\):4924-32. ) /Pg 29 0 R /K [10] >> endobj 557 0 obj << /Type /StructElem /S /P /P 823 0 R /E (Expression localisation and functional activity of pituitary adenylate cyclase-activating polypeptide, vasoactive intestinal polypeptide and their receptors in mouse ovary. Barberi M, Muciaccia B, Morelli MB, Stefanini M, Cecconi S, Canipari R. 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t͛M|BG"̀Dӳn2ff)=ܑ]V-^̥!@06w Gc1E1H2Qpw$<+6/\hέ1Ry >hSL^>иlmh,DOX\il۞hֻOj~4*Z xw$پ@T4{n[@04UADV$ B")<ÜA ͝K)0B W@T:O#()r ;oډ%]B^{߷j,lb׳b7 }?6޴C͑5hH[8X=nQXfyj?{mY/m^oYyڝ\)BC IKܤ8yLSg&$PRkr2Md\ves9Ԛ 㦖%kjk֔m 1~KorbWm=u@k]R7}*-ٸ]+k͏쨮{f\8_Scsss9"s _c9raVa endstream endobj 1432 0 obj << /Length 3821 /Length1 13080 /Filter /FlateDecode >> stream xY{l[yCo(|+J2ｔ-KbMꑈJL8iHSƶXYrz--f -HaRd@yC+i%݀ImAaY4+&KJy},};u%H05zz/͵ ;.{ܹy>Tr䏟~፷ƿ*|<{6[ y w0m3E93^k9Ee$8#`۾ق^؁vlY䜬K5>GF:&P Ph؅=TJ"`"1%LbrPz5e%-S@$ľ3˶YN-^QE mRcCR˴!Sk._ߐTZĂ]yrصh kf.份oR+cO(ڿ'ܡ5}js@YU[?Vկ,dBCʏ+B "`Lb ɲr%t1@= UR'L}s$nnUy+Pt",Z)`wsK/~`<|,m7{>ݲ7ſ‡D۝6vl^>+x|c$?0i|seq{j~# `Ķ1& 02C^U$Y%%La@B;fv1;Xk֋Y]lH{mku{o>/{ {[+/Ƃ}_Mھ_TH^_IM}^I#၉l-7T:%d)f\2so(N$!IQ()e2!gI+^ktonTW] <ފFjYٻȢ7 d._T?)e|zn~ԷK>Bkf9?@0<3U;+'/>f!Ïۋ7A䣐I)YX аr*ֳҳ?{|-3Ѿ7Dw *~YHF6oD5m{gѕwqb3?dGILQ0vM6^eVhiڸ *tz$%_XX|a~;w͝07'}ŗ /^|щW~晧 J͸/IͩtBe LfD(ʼnU\$1V},ONe&Y\[`GZѢ3q5Lkw34ŽKwMu͝{"州 s|z&ZoSЇ*-&qt7V^^-[kk;LOdIҺ(((6~F08HzI͌H9 t{"@: dZi rJ"&bj\ ZGɰQ8kkIJqEUZ ʼn5iP*m 96ԈeW@q]lBƢ8U'3$\[|ah1g4z8MZR LgeYWPx7tZI nRa3 [oز͆bت %x݂G-|#7)1Iw9 PհѦ 4lIvÖ [ðUCӰ݂wGn n<괚i exB#I8`2DE 2u2&[TBjoe& *kMowǗ{ яBLpG7GA5M3x_B";hRGMePbܠI [BSGxxI Q(kZĵŗkl4hH r MӅy0hm7yh-.P2yH_WNyw' 2$>(e=TDfJ#9JIJd$'2螬9)Xv0'1FR< x)Ƚʒ1tBTx82iRI{5y8|LjEJtG`@x\Rrj]!RCw Q*6[ Zx=4RL#A7ixMZ݌ϠA}Cqn GE7PD7)aͥ(h%s#QBߠ?% J>d?&jX y 4%IBa5?l҄A&%EF5c-IC#%u4ݤ%0!7IKQݤ#C###O7n=#nҽ##F ̘nҧF2#u r#)´A<#&4tܑuN8[nI?-&AGS$ Aψu$;~Ơk91qgI@I@^EZ3MrG;ńrH7n7X==$Hَ=>܊$#D73yT2Le*ST2LeJ:}La/ endstream endobj 1433 0 obj << /Length 10944 /Length1 22840 /Filter /FlateDecode >> stream x| xy?@$xbM )DR' CHH:|HlӲd[|Щe;>bʒ'6M$mRI&4u9HJ~O;43ς@ Xך  ַ+>nbM7uA5\Y`p|MP߿=>1zG}61((2=cZt^h~tk}1`C7ZB~ҕ𓹮p!Ko\'?V]Oz^5R~r᧮,ߐRO _z.H|ע`1&)kNc04CS&wwB8N϶'/9@Kg G@ WGf3*W`C/nl3PDnqJe[*ek,H]3 ̀>u.o)@S=185!@tpoF>e(Lz+h>>eo >z^;B5u qȋ9=1V[ LSx:|f nm=LS_>(uKG{.n^sk^'e"tM>l*@8&xͰ6BI̿  S2C@-ܲDŻQZΠjG ݅F'=$K_C5(`Ai hA0 ̐ Y`<7J!ua+lAAO1VPFB9nE8FOm Z0٦`-A4ʯKFuh_?2jZ|1?/a]5qCdl6 rGED>aEZfA8+rA\?'-΍n o;/6N&h;'87# whUݑ92"*Ҫbh&"O4*F}"Z9v9 wGDF|TD1H{^f[##"k"0w;*"L igO$mF(ω5yl}"a,`5WT!AEmPD}"LOTx9: 82E HEBRU!*潔*yD#ƵDF)r61ry\,莐Wz(+4VQ&"'j3(qbz<ΉB(*j'jP'꼜X½BCQ!.j1hBHzo -5>hvD:ȝ6>Z  "3:]XD%#4N`GHD)Gwd0OG9E xm#!D2Q^EhEI2zapڈB\BJX(^@ LzlO4ygf ";ImPФ0ΰyg(II#uhO,}Gjy^5D;H{g0Ԃw&uw!;ÒQQI#Kr1Q‚baI(&z#|bq# !^-7BO,YE3 2FJK92/W)[~%"\,/HϖFz |b}">Ī}>1`qp~n1^;V=LX&Ĺ6qBh !'V{EC  W',s~yBcރ=38줲!a A m1_nJ1dgñ~AqHc]L\8v mj *m"vʰw1{*NBCB⻢>8q&y W:[T !ڄeeDZIڈx8\R,g"Xtu% NJF jܐ M,ϗeWkm#\}?G&OlZ^0^sIC^sꉲH .Q.BurvJĿ 6~hVŒm~^H2 I˼"ebFXQN Q,^1P;Zϵ)>uz:; 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, H,?FJ0ZF{)  d"E). x.d={jeB<# @hu v҇L~ vhz)isv|=N1 3HZ)Gy3=(lLau`AJ*x_ޝ,Uy/%F.Mwl1.?jDM(@Uw )iV\_ait%ՠaJ'}Ww'J!S$Aj+ .ڠSR a0#9 ȟ'Qx y%߄#%9L)\~"h+@Rňpl@f D xQ#Rmxir@n~&^kQu[Vt3 Z_ZMЫO?;7v~XwƱWB6H9z_^D^@_G#Ϧ~H$x30|V!CYMa`3ȑW򆊀BcQtP95ɶj̉)^;jNWD?k ͜r>C/7JP|cEmRPEhQbkآ7*pn lZVJ/tl˒SaYZ&V&̏!(NyQɹ*7izԵF1'1A%qo5R]hL|rbAhL?AceY&*.7[pyAUK=+Pd xF;Ƿ?;Qu뻚&\Sxcz뚮 5F{^-*3;ߙ_nex(S$zkSEc4"a"N %OyF{^w599!{ud;SYEFa?6CZ6"+Ʉa4qx-`LK٠K)pV 5/t{:B##!pteω߱}VO+$q-UBO΄2"Ooo $F]q㍂ N,?`xM/іrWvwU׺g_Ygͮay/o~OY9ڕ\ASIH;|Ոq;DďJsM.KIyK&o\k"6tH]Ț•cmx3ט7Ǐzgg}=o?qײP~~ho~nZ,TZ 9眽c;kjv޿Ygї' endstream endobj 1434 0 obj << /Length 3821 /Length1 13080 /Filter /FlateDecode >> stream xY{l[yCo(|+J2ｔ-KbMꑈJL8iHSƶXYrz--f -HaRd@yC+i%݀ImAaY4+&KJy},};u%H05zz/͵ ;.{ܹy>Tr䏟~፷ƿ*|<{6[ y w0m3E93^k9Ee$8#`۾ق^؁vlY䜬K5>GF:&P Ph؅=TJ"`"1%LbrPz5e%-S@$ľ3˶YN-^QE mRcCR˴!Sk._ߐTZĂ]yrصh kf.份oR+cO(ڿ'ܡ5}js@YU[?Vկ,dBCʏ+B "`Lb ɲr%t1@= UR'L}s$nnUy+Pt",Z)`wsK/~`<|,m7{>ݲ7ſ‡D۝6vl^>+x|c$?0i|seq{j~# `Ķ1& 02C^U$Y%%La@B;fv1;Xk֋Y]lH{mku{o>/{ {[+/Ƃ}_Mھ_TH^_IM}^I#၉l-7T:%d)f\2so(N$!IQ()e2!gI+^ktonTW] <ފFjYٻȢ7 d._T?)e|zn~ԷK>Bkf9?@0<3U;+'/>f!Ïۋ7A䣐I)YX аr*ֳҳ?{|-3Ѿ7Dw *~YHF6oD5m{gѕwqb3?dGILQ0vM6^eVhiڸ *tz$%_XX|a~;w͝07'}ŗ /^|щW~晧 J͸/IͩtBe LfD(ʼnU\$1V},ONe&Y\[`GZѢ3q5Lkw34ŽKwMu͝{"州 s|z&ZoSЇ*-&qt7V^^-[kk;LOdIҺ(((6~F08HzI͌H9 t{"@: dZi rJ"&bj\ ZGɰQ8kkIJqEUZ ʼn5iP*m 96ԈeW@q]lBƢ8U'3$\[|ah1g4z8MZR LgeYWPx7tZI nRa3 [oز͆bت %x݂G-|#7)1Iw9 PհѦ 4lIvÖ [ðUCӰ݂wGn n<괚i exB#I8`2DE 2u2&[TBjoe& *kMowǗ{ яBLpG7GA5M3x_B";hRGMePbܠI [BSGxxI Q(kZĵŗkl4hH r MӅy0hm7yh-.P2yH_WNyw' 2$>(e=TDfJ#9JIJd$'2螬9)Xv0'1FR< x)Ƚʒ1tBTx82iRI{5y8|LjEJtG`@x\Rrj]!RCw Q*6[ Zx=4RL#A7ixMZ݌ϠA}Cqn GE7PD7)aͥ(h%s#QBߠ?% J>d?&jX y 4%IBa5?l҄A&%EF5c-IC#%u4ݤ%0!7IKQݤ#C###O7n=#nҽ##F ̘nҧF2#u r#)´A<#&4tܑuN8[nI?-&AGS$ Aψu$;~Ơk91qgI@I@^EZ3MrG;ńrH7n7X==$Hَ=>܊$#D73yT2Le*ST2LeJ:}La/ endstream endobj 1435 0 obj << /Length 3654 /Length1 6572 /Filter /FlateDecode >> stream xXl}wG%ʴ~X6cQ'%뇣زMH+,[㚴HYvlKκI,ftmX ú이tYlcSu+!Ku X7 McnGJC|wNȝ<_/f/r3 K$߬0nمK=hh`+\z{kE P̾bP`7 Asזn4 ߽:?Wuo8د7|k} # 7o`$_X,.X+y?ntqHgfC^1/oM._.}G}ō~byƑ jD}ķa.50Ԃj0fx\w)?\qLb\pݬ5~}WLe<^;@3 j_F,b4Iԟ5O1[/P]3<7#>T|^ӽེ{竍y%&R^'{TF%^xF!u03̙ Ql6Q9ig>&+Z8R+OVE,Ry=P kxKʏ<⽼T4+H7"׭|Gs)Iv4g_ܸnin*{a?.0_c+1dO!ȿ:jpH`Wح*f+U`Kvhj:ڪڽS*xy܆$q<"q1@}Xf3X0.{Н 10 RܸH{tmv!>ߺ&nXA)G #w}YWN{>y>slCOmӱޏ%w:}0֚)zjGUWZKQbBc%jBUaw A/2k[^eĮWnWu=Z'>p06FhC.jB,4)=K o?@_MwT* ]c`2 ;۶Ԣ5jm_GR׃U:Drvxlw#C{'»&O }/F_,8<;6"ݓ'{ziUzpaz;֪c{A#~]H54j ]Hr9{OtS{􅮁;mW{iۙNv]:4;A^8< C ;NOY!+d EwOWmOW[Cyghn FzEL%ͽnO5~sjٱH)ԓ|;qZ+؝4atb әtVq<5f`Xugs4Q<#7c] G" YJ-%ŤYGq) BݛTfnVgʟDNDHjr2QlXaB٬*|AuOf"ՙP}$#ɌR^L., Y}¹l6Vf-L1u!EZ(3/s'3g%J#b9GҊXQ|$q*_.=XD(+J:MSٌdJ(f)GqeJRXIK(XɼgQ,|1GHAnqg4qQeKPrf t2Y}|u+̶\eFs"]]/JUbJʈZTŖ )'6S:-uF: [l,qV|QAXNUPV2h6Jf(ڪK"41S*D)'TJZ*d%H/@cjiRmHSp-rn%)I{5.c+'^)ĨxHE'e)ֲV|%nGR x$KԉbiJ~B J1"FvԐoqԾ;3Gq1JOcҨ5jEbNV+昣Bj%UfTTkKqKҰ{"[ʴ*GFTf CWx34ќ2?9:* 2|a2+Aa%2ᰥQţ*j/9rdn#VEEu\arT~+kuB(_WȰT@ˏZ䔺7^>JZaň SEAqU豍oJ6NYn]kU>>Z{IKĩGV73fH6YH“H8#R ?aR#J*Ӎ(WL{s'--1"pjJz3\#xgo) :Fpdd1a{GUD5GBK_=Mq5sY?&=&5sԘT5NuK[".ZKjvԄ\RNe0'2+rSIێ"!p8 #gB++%#tx#FOOӵqI$#9j;"q@8:YK:.Bs:.Bu\="tUEL5_mG-P,a;i*gsCsX$=XiHV oIU +U ~NzY =@XpBEຽO陦TDte**T ʕZ}&m(*s{W{ endstream endobj 1436 0 obj << /Length 10586 /Length1 22164 /Filter /FlateDecode >> stream x| tǕ @l" h ./ @R:,@ )QHJl>$[VhYv|&ٲRI&-a&s$b@3snalc17=_[N(fu W,nG~ԆjAFA@ H5h@ :@FȂl@>`B %P ~e6A{F6i(©:%|c{:T,ґ:; 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